• VARIOUS DRUG INTERACTIONS AND THEIR RELATIVE EFFECT

    • March 5, 2018
    • Posted By : admin
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    •   184 views
    1. Aluminium Hydroxide Gel + Pseudoephedrine = Decrease effect of that drug due to increases pH of gastric fluid
    2.  Ciprofloxacin + Theophyline = Increases plasma level of Theophyline
    3. Aminoglycoside + beta-Lactam antibiotics= Synergestic  effect  but  if given  in  same syring   it‘s   become   inactive   due   to complex formation
    4. Cortisone + Ampicillin= Antagonist
    5. Erythromycin /Clarithromycin/ Telrithromycin + Carmazepam/ Phenytoin = Increases  level of    Carbamazapine  and Phenytoin
    6. Methotrexate + Sulfamethoxazole  = Displace from binding site and increases free plasma concentration of drug
    7. Amphotericin B + Flucytosine = Synergestic effect
    8. Ketoconazole + Amphotericin B = Antagonized   effect   due   to   decreases ergosterol level
    9. Azoles ( including All) + Terbinafine = Contraindicated
    10. Posconazole + Ergot alkaloid = Contraindicate
    11. Cimetidine + Terbinafine=  increases plasma concentration of Terbinafine
    12. Gresiofulvin + Alcohol = Potentiate toxicity of alcohol
    13. Miconazole+ Warfarin = inhibit metabolism of warfarin
    14. MAO inhibitors + Pethidine = Hyperpyrexia
    15. TCA + SSRIs TCA =  toxicity
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